Sentence examples for marker of benefit from inspiring English sources

Therefore, Oncotype DX has also been considered a predictive marker of benefit from chemotherapy.

The consistency of these baseline and on-treatment results suggests that Ang2 may be an important marker of benefit from anti-VEGF therapy.

Therefore, MGMT promoter methylation represents an independent favorable prognostic factor for GBM patients and a predictive marker of benefit from alkylating agent therapy in GBM [ 3].

We confirmed previous data indicating that PgR, although prognostic, is not a predictive marker of benefit from AI vs tamoxifen (Dowsett et al, 2008; Simon et al, 2009).

Mismatch repair in colon cancer has been indicated as a predictive marker of benefit from standard adjuvant care, fluorouracil-based chemotherapy (Sargent et al, 2010).

However, whether bcl-2 is a predictive marker of benefit from the specific adjuvant chemotherapy AC/T, which contains paclitaxel, is not clear.

Gene expression profiling has been frequently used for developing prognostic signatures but much less frequently for developing predictive markers of benefit from specific treatments.

Furthermore, no strong markers of benefit from erlotinib therapy were found in additional exploratory analyses on the basis of different definitions of clinical benefit (including PR + SD versus PD, PFS ≤6 weeks versus PFS ≥24 weeks and PFS overall), response to previous treatment, analysis by gene sets or grouping by biological pathway or chromosomal location.

Recommendations for adjuvant systemic therapies are based on estimates of life expectancy (prognostic markers) and of benefit to therapy (predictive markers).

For example, DNA methylation of MGMT is considered as both a prognostic marker for patients with glioblastomas as well as a predictive marker for benefit of the use of the DNA alkylating agent, temozolomide, in the management of this disease [ 2].

This result also suggests the definition of SMAD4 as a predictive marker for benefit of 5FU-based chemotherapy in patients with colorectal cancer.