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However, our present data indicate that there is no correlation between ALDH activity and the clonogenic/tumourigenic capacity, or enhanced drug-resistance, providing additional evidence that ALDH is not a universal marker of aggressive tumourigenic cells.
However, in ovarian carcinoma, ALDH has been found to be a favorable prognostic factor [17], suggesting that ALDH functions as a "marker" of aggressive tumour cells in some contexts, but not in others.
Our results suggest that Podocalyxin is a potent regulator of epithelial cell morphogenesis, which may provide mechanistic clues to its previously described role in blocking cell adhesion and as a marker of aggressive cancers when overexpressed.
These studies imply that ECI is a biologic marker of aggressive nodal disease.
This work establishes DKK1 as a potential prognostic and diagnostic marker of aggressive breast cancer types.
HER2 is a major marker of aggressive breast cancer and an important pharmaceutical target [ 28, 46].
Similar(19)
To identify novel epigenetic markers of aggressive bladder cancer, we utilized a high-throughput DNA methylation bead-array in two distinct population-based series of incident bladder cancer (n = 73 and n = 264, respectively).
Low snoRNA expression correlated with markers of aggressive pathology.
Li et al. reported that high levels of AR were associated with increased proliferation and markers of aggressive disease [ 19].
These data indicate that ERBB4 overexpression alone increases in vitro markers of aggressive behaviour in ES cells.
Associating with markers of aggressive disease, it may play a role in the type II serous ovarian cancer pathway.
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