One criticism of our study is that because we studied stable outpatients we were unlikely to find evidence of ubiquitin ligase activity, since this is a marker of active muscle atrophy.
Detection of B19 virus DNA in serum is the best direct marker of active infection.
Antinucleosome autoantibodies were previously described to be a marker of active lupus nephritis.
The presence of HHV-6 DNA in plasma or serum is considered a good marker of active infection.
While in this study we focused on H3K4me3, a marker of active promoters, the chromatin marks often co-localize and there is, indeed, a H3K27Ac peak in close proximity to the index SNP.
Previous studies have suggested that the detection of HHV-6 DNA in plasma is an accurate marker of active viral replication.
LoNA-overexpressed N2a cells showed decreased levels of histone H3 tri-methylation on lysine 4 (H3K4me3, a marker of active chromatin), increased levels of H3 di-methylation on lysine 9 and H3 tri-methylation on lysine 27 (H3K27me3 H3K27me3, both markers of repressed chromatin) in rDNA promoters (Fig. 3i) and coding regions (Fig. 3k).
Headache was thus a poor marker of active disease.
Thus, FLT uptake is postulated to be a marker of active DNA synthesis in vivo.
Then the scientists assayed the animals' brains for the c-Fos transcription factor, a marker of active neurons.
Colour and power Doppler may be utilised to assess increased vascularisation, a marker of active inflammation, to differentiate between active and quiescent disease [14].
