Sentence examples for marker of aberrant from inspiring English sources

Because our preliminary data point to nucleolar localization of HSPC111 in association with ribonucleoproteins, it may be either functionally associated with these processes or a marker of aberrant cell growth regulation in general.

Lack of PR expression in ER+ tumors may be a surrogate marker of aberrant growth factor signaling [ 3] that could be associated with their more aggressive outcome, as has already been described [ 4].

In previous studies, loss of PR has been suggested to be a marker of aberrant growth factor signaling and has been associated with one mechanism for endocrine resistance[ 11], and several studies have shown that ER + PR- tumors exhibit high expression of epidermal growth factor receptors [ 1, 4, 7- 11].

Thus, markers of aberrant methylation may be a potential gateway for monitoring and determining the prognosis of bladder cancer.

Infiltration of the epidermis by CD8+ lymphocytes was reversed and staining for markers of aberrant epidermal differentiation and vascular inflammation (keratin-6 and E-selectin) was significantly reduced.

The identification of concomitant genetic alterations or other markers of aberrant signal transduction in the same tumor samples used for BRAF mutation testing will set the foundation for exploration of markers of response or resistance.

We therefore assessed the effects of the different dosing regimens in KPC tumours by immunohistochemistry for proliferation marker ki-67, apoptosis marker cleaved caspase 3 (CC3) and phosphorylated histone H3 (pH3) as a marker for aberrant mitotic figures.

From examination of the various criteria and instruments previously identified, surrogate markers of indicators of aberrant behaviours suggestive of problematic prescription opioid misuse were proposed for this M-PEM study based on the Chabal criteria.

The surrogate markers of indicators of aberrant behaviours proposed for this M-PEM study reflected most closely the criteria proposed by Chabal et al. based on behavioural not clinical manifestations.

On multivariate analysis, only increased EGFR expression (protein or RNA), the presence of metastasis and/or recurrence, a high tumor grade (GII &GIII) and a combination of aberrant markers (≥ 2) were significantly associated with reduced OS rates (p = 0.022&0.025, p = 0.000, p = 0.001, p = 0.001).

Genetic markers and manipulation have deepened our understanding of aberrant cancer signaling, growth, and proliferation[9].