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Despite its potential merit, this property comes at the cost of a substantial loss of statistical power by the fact that genotypes at each single marker need to be decomposed in order to correct for population stratification and test association simultaneously.
Preclinical trials in order to overcome the difficulties of developing a consistent delivery system with nonmigratory marker need to be conducted.
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The antibiotic resistance marker needs to be exchanged to a food-grade selection marker.
To obtain clear genotype data, the previous DEP1 marker needs to be improved.
A good prognostic marker needs to be highly specific so that false positives remain low.
Instead, the effect of each single marker needs to be estimated with high accuracy.
Consecutively, this serum marker needs to be approved in a larger and ideally prospective setting.
However, all the predicted molecular markers need to be validated.
But the markers need to be removed by linear interpolatioin further.
However, allele-specific markers for yield-enhancing genes have not been developed yet for some major yield-enhancing genes or the existing markers need to be improved for an effective marker-assisted breeding program.
Therefore, multiple markers need to be analyzed simultaneously in order to distinguish these innate cell populations.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com