When assessing the precision of the osteotomy measurements, the centre of gravity of the marker model of the posterior calcaneal fragment made up the fixed rigid body reference and the marker model of the anterior calcaneal fragment made up the migrating object.
For the CC joint, the centre of gravity in the anterior calcaneal fragment made up the fixed rigid body reference, and the marker model of the cuboid bone made up the migrating object.
With this choice of RK, the estimated residual variance was 0.41, which suggests that the RKHS model fitted in Box 10, fits the data slightly better than the pedigree + markers models of Box 9. Box S4 of File S1, provides supplementary code for the model fitted in Box 10.
We also tested multi-marker models to determine the value of combinations of biomarkers.
The 5 marker model consists of 7 rules containing all relevant interrelationships between the 5 selected markers.
For each marker, appropriate models of nucleotide substitution were determined by the hierarchical likelihood ratio test implemented in MrModeltest [ 36].
Leave-one-out analysis in the single (prioritized) marker model confirmed the lack of a dominant study and the stability of the pooled calculations.
For QTL mapping in the RILs, we used a single marker model, with the percentage of total progeny at a certain stage used as a phenotype.
To investigate the effect of tumor site, measurement precision, tumor surrogate correlation, training data selection, model design, and interpatient and interfraction variations on the accuracy of external marker-based models of tumor position.
SAP also decreases the expression of macrophage activation markers in models of pulmonary and renal fibrosis [ 8, 9].
