Moreover, a multi-marker model has been assembled which accurately distinguishing patients with NSCLC from smokers with no known malignancies.
Single-to-several marker models have at best shown a sensitivity/specificity of 0.87/0.83 in infants [ 16].
We showed that, in theory, different allele coding methods led to the same inference in marker-based models when the model has a fixed general mean effect.
These networks have been associated with different anatomical locations, neurotransmitter systems and genetic markers [ 23, 24], and the model has inspired studies of attention deficits in ADHD as well as in other neuropsychiatric disorders (see [ 25]).
Such a model has been proposed for cervical CSC markers as well [ 6].
The marker assay patents and the patent application for the statistical model has been licensed and commercialised as the 4Kscore by OPKO Diagnostics.
Levels of all markers included in the model had been shown to be highly correlated in serum and EDTA plasma (Additional file 8: Table S4).
Sodium fluorescein used as a barrier marker indicated that the rpe model had excellent seal integrity.
The remaining markers, not included in the model, had minor and/or redundant effects with those ones.
Elevated pro-hypertrophic markers in the αMHC-MerCreMer model have been reported previously, although higher doses of tamoxifen were used in these studies (40 mg/kg daily for 4 days, 160 mg total) (Andersson et al., 2010).
No significant correlation between CD26 and other studied markers were found.> A binary logistic model having gastric cancer as the dependent variable while age, gender, CEA, CA19.9 and CD26 levels as independent variables, showed that CD26 serum levels were independently associated with gastric cancer presence (Table 2).
