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Likewise, an increase of tumor marker level of 20% or more was defined as biological progression.
A decrease of tumor marker level of 20% or more was defined as biological response.
The logarithm of the ratio of treated tumour volume (tumour marker level) to the volume (tumour marker level) of corresponding non-treated tumour is a general continuous quantity for tumour response to both cytostatic and cytotoxic agents.
Unfortunately, EGFR-TKI treatment was not effective in the tumor regression nor tumor marker level of present patient (disease might be controlled), but treatment with an ALK inhibitor resulted in SD with decreasing tumor markers.
This indicates that, for example, the odds of death for a patient with a marker level of 3.0 is 5.4 times that of a patient with marker level 2.0.
Along with macrophage activation, a high proliferative response of T and B lymphocytes to the mitogen stimulation was observed in the germanium biotite group compared to the control group, thereby indicating that the marker level of lymphocyte activity in the germanium biotite group was higher than in the control group.
Similar(53)
The serum tumor marker levels of CEA, CA19-9, and CA125 were 28.7 ng/ml, 60.6 U/ml, and 302 U/ml, respectively.
The STATInS trial is a phase II, randomised, placebo-controlled study of the safety, pharmacokinetics, and effect on inflammatory marker levels of atorvastatin in intensive care patients with severe sepsis [75].
The marker levels of none of the candidates (SYCN, AGR2, REG1B, or LOXL2) showed a significant correlation with age (Additional file 1: Table S3).
When the cases of lead time were included a concordance between clinical evaluations according to WHO response criteria and evaluations according to changes in the marker levels of 74% was found.
The STATInS trial is a phase II, randomised, placebo-controlled study of the safety, pharmacokinetics, and effect on inflammatory marker levels of atorvastatin in intensive care patients with severe sepsis [ 75].
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