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The percentage of cells positive for each surface marker is presented as mean ± SD and median and range.

The sensitivity, specificity, positive and negative likelihood ratio (LR) as well as their 95% confidence interval (CI) for each marker is presented.

The percentage of cisplatin-sensitive and -resistant cells that show co-localisation of the proteins with the Golgi marker is presented in Table 2. Median percentage values were calculated from five individual images.

The scan – rescan precision for each marker is presented in Table 2. Results for the individual and aggregate biomarkers for use as diagnostic markers (Kellgren and Lawrence index ≤ 1 versus >1) and as prognostic markers (early progressors versus non-progressors) evaluated in the 21-month longitudinal study with 159 subjects.

The generation of a tissue-specific biochemical marker is presented in Figure 2. The enzymes in the inflamed joint generate specific biochemical metabolic products from the extracellular matrix; the actual protein fragments of type II collagen and aggrecan that are the result of pathobiological actions in the joint are schematically presented in Figure 3.

Similar(55)

The allele dynamics for each marker are presented in Dataset S1, figures S1, S2, S3, S4; Tables S1, S2.

Genotype frequencies for each marker are presented in Table 2.

The primers and sequence that was analyzed for each marker are presented in Table  1.

Ae, AUC, CL, CLR and CLNR values for each marker are presented in Table  2.

The loading plots for each type of marker are presented in Figure  4.

Detailed information regarding the assays, range of detection, and standard values for each marker are presented in the Supplementary Data.

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