After the first screening, the density of markers was increased on chromosomes 2 and 6, which were shown to be linked to the trait.
The same markers were increased on a sample collected after chemotherapy and reduced back to initial level in recurrent tumor samples, suggesting their role in recurrence [ 32].
York, M. R. et al. A macrophage marker, Siglec-1, is increased on circulating monocytes in patients with systemic sclerosis and induced by type I interferons and toll-like receptor agonists.
The data show that protein levels of the adipogenic marker aP2 were increased on day 14 by as low as 1 μM BPA; however, only 25 and 50 μM BPA treatments showed a statistically significant increase in aP2 protein levels relative to control (Figures 3a and b).
The CD69 expression, a marker of early activation, was increased on CD4+ and CD8+ cells in arthritic mice.
Moreover, bone turnover markers are increased in patients on antiretroviral therapy and vitamin D deficiency is prevalent in HIV-infected patients.
Furthermore, the occupancy of both CD206 and CD163, two TAM markers, was found to be increased on the surface of mutp53-reprogrammed macrophages (Fig. 1d, Supplementary Fig. 1h).
While early activation markers such as CD86 were increased on the surface of DCs, SNs of treated B16 cells did not impact on the expression of CD80 or CD40 on DCs (Supplementary Figure 4).
In addition, levels of the T cell activation markers CD134 and CD137 were increased on CD4+ and CD8+ T cells after culture with PA2024, and there was evidence of B cell maturation and activation [ 20].
In contrast, in tissues treated with ODN M362 there were no statistically significant changes in the fraction of CD4 T cells expressing the activation markers, except for HLA-DR which was increased on the CD3+CD4+CD8− cells that migrated out of the tissue blocks (122±7 of the untreated tissue, p<0.002).
