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The index did not provide independent prognostic information when the alternative pairings of p53/pRb and p16/pRb were also included in the model, which perhaps reflects the inherent overlap in the information provided by the three marker indices.
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We also developed a new non-invasive serum marker index for this purpose by evaluating several clinic-pathological features.
Based on the marker index value obtained, AFLP is found to be more efficient in detecting diversity among 10 CPTs.
Thus a convenient quantitative estimate of marker utility and the polymorphism detected can be given in terms of the mean heterozygosity and the marker index [ 18].
The negative association between callous traits and AI/ACC response could reflect an early neurobiological marker indexing risk for empathic deficits seen in adult psychopathy.
The marker index (MI) values calculated for ISSR and RAPD for T. foenum-graecum were 1.53 and 1.51, respectively while in T. caerulea they were 3.17 and 3.35, respectively.
Blinding for the results of the marker (index test) when interpreting the reference test (and vice versa) was fulfilled in about 55% of the studies.
Differentiation between markers was seen in their effectiveness to discover polymorphism, as SRAP markers had a marker index (sensu Powell and Morgante, 1996) almost twice as high as EST-SSR.
Polymorphic information content (PIC) varied in the range 0.33 0.49, 0.18 0.49 and 0.26 0.34 for RAPD, ISSR and AFLP markers, respectively, whereas the corresponding average marker index (MI) values for the above markers were 7.48, 6.69 and 30.75.
Since this study was focused on the prognostic role of molecular tumour markers, an optimal cutoff point of marker index was determined that allowed best separation of patients into those with favourable and those with unfavourable clinical features and prognosis.
We represent an observation of the maximum LOD as M, where M is defined as the pair, with δ the magnitude of the max LOD value and λ the location (marker index) of the max LOD value.
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