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Taken together these findings suggest that mir-143 could be a tumor suppressor and a potential novel diagnostic or prognostic marker in prostate cancer.
It may therefore serve as a prognostic marker in prostate cancer [ 70].
Therefore, TRPM8 channels can be considered as a valuable prognostic marker in prostate cancer [ 23].
Hence, it was hypothesised that the level of expression of stathmin may serve as a prognostic marker in prostate cancer.
Only two studies have reported on the marker in prostate cancer (Carnell et al, 2006; Hoskin et al, 2007).
The expression of MMP26 was also found to correlate strongly with Gleason score, indicating its potential as a prognostic marker in prostate carcinoma.
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Trojan L, Thomas D, Friedrich D, Grobholz R, Knoll T, Alken P et al. Expression of different vascular endothelial markers in prostate cancer and BPH tissue: an immunohistochemical and clinical evaluation.
Johansson A, Rudolfsson S, Hammarsten P, et al. Mast cells are novel independent prognostic markers in prostate cancer and represent a target for therapy.
Additionally, the clinical response criteria used for these tumor entities are complementary: Conventional RECIST/WHO criteria in RCC and combination of radiographic criteria with biochemical markers in prostate cancer.
However, other studies have shown downregulation of the very same markers in prostate cancer-associated stromal cells (26, 27).
Therefore, the potential clinical application of low-prevalent fusion gene markers in prostate cancer detection has yet to be reported.
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