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Exact(9)
However, the additional cost of measuring the marker has to be taken into account.
This marker has to be further validated in clinical settings, as well as for other tumour entities or combination schedules.
Whether it can be used as a prognostic marker has to be elucidated in further clinical studies.
Hence, to achieve reliable results that are comparable between both imaging modalities, a hybrid marker has to be applied.
Any novel risk marker has to be tested against the accepted gold standard for its additive predictive value.
Therefore, segregation of the observed phenotype of a mutant with the selection marker has to be evaluated for several progeny.
Similar(51)
Reportedly, the marker had to find an expert to decipher it, and there was some discussion before the score was given.
In order to confirm that isolated bacteria were from intestinal origin, a definitive marker had to be established.
The specificity and selectivity of this putative trait-marker has to be investigated in follow-up studies.
However, the marker registration is associated with high logistics, since the markers have to be placed prior to data set acquisition and have to be kept in their position until the patient enters the operating room.
Finally, iv) surrogate markers had to be described.
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