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A sequence similarity search resulted in the development of a plant universal marker for wide cross-species amplification.
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Thus as a putative CSC marker for a wide variety of tumor entities, CD133 (AC133) is one of the most intensively investigated of the known CSC markers.
Low HRV is associated with increased risk of all-cause mortality and is a marker for a wide range of diseases.
GDP growth is a surrogate marker for a wide array of physical, social and institutional improvements that can support better health, so we use it along with time trends as a summary statistic to produce the minimum performance target.
However, individuals assigned to intensive therapy who failed to improve control to A1C levels <7.0% (<53 mmol/mol) in ACCORD fared poorly and had more severe hypoglycemia, and severe hypoglycemia was noted to be a risk marker for a wide range of medical conditions in ADVANCE (14, 15).
Methylation levels of cytosines in CpG dinucleotides of repetitive elements has been used as a surrogate marker for genome-wide methylation [30],in this study, LINE (Long Interspersed Element) 1 and Satellites 1 and 2 were selected as surrogate methylation markers.
LINE-1 methylation status is a well-known surrogate marker for genome-wide DNA methylation level.
Its methylation status has been used as a surrogate marker for genome-wide DNA hypomethylation in many cancers [ 19, 20].
Global DNA hypomethylation is an early event in colorectal carcinogenesis, and long interspersed nuclear element-1 (LINE-1) methylation status is a well-known surrogate marker for genome-wide DNA methylation levels.
We calculated the frequency of NCO GCs (defined as the ratio of converted markers divided by all markers) for a wide range of minimal coverage thresholds.
33 We agree with these authors, who note that psychotic symptoms appear to be important risk markers for a wide range of non-psychotic mental health disorders.
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