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Lorglumide, a highly effective competitive ligand for the cholecystokinine-A receptor (CCKRA) was conjugated to a fluorescent dye and a magnetic resonance imaging (MRI) contrast agent to obtain a bifunctional marker for tissue with high CCKRA expression.
Lactate, a marker for tissue perfusion and oxygenation, that was increased by 3-fold after CLP and was significantly suppressed by 37% after BRL-44408 infusion (Fig. 7F).
This treatment significantly retarded the growth of the animals that at the end of the experiments showed a decreased weight in comparison with the untreated controls, strongly reduced the levels of circulating thyroxine, and also markedly decreased transcript levels for deiodinase 1 in liver, a sensitive marker for tissue hypothyroidism [35].
Thus, it is an unspecific marker for tissue damage, e.g. caused by necrosis.
Endothelial injury was quantified by wet to dry weight ratios, a surrogate marker for tissue edema.
In this study MDA was also used as a marker for tissue injury.
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These data clearly suggest GOLPH2 as an additional ancillary positive marker for tissue-based diagnosis of prostate cancer.
Indeed, p62 accumulates in several autophagy-deficient mouse tissues (Zatloukal et al, 2002; Martinet et al, 2013) and represents a reliable marker for tissues with reduced autophagic activity (Waguri & Komatsu, 2009).
Genetic markers for tissue site preferences for infection lie within the emm region (denoted emm pattern), and are used to define throat specialist (emm pattern A C), skin specialist (emm pattern D) and generalist (emm pattern E) strains, with each group having a predilection for causing infection at their respective tissue sites [7].
Biochemical examination of serum markers for tissue and organ injuries indicated no significant changes compared to the vehicle group (Table S3).
Studies of pulmonary fibrosis-sensitive mice have shown positive correlations between tissue and serum cytokine levels, suggesting that blood indices may be used as surrogate markers for tissue cytokines [ 19].
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