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The neuraminidase of all the Indian isolates possessed H275, the marker for sensitivity to the neuraminidase inhibitor Oseltamivir.
All the Indian isolates possessed residue H274 (position 275 in N1 numbering) a known marker for sensitivity to the neuraminidase inhibitor, Oseltamivir [17].
Furthermore, HJURP is a predictive marker for sensitivity of radiotherapy, indicating levels of HJURP mRNA and protein in breast cancer patients are clinically relevant.
Our immunohistochemical analysis further suggests that the ALKBH3 expression profile of tumours may be a predictive factor for tumour recurrence of adenocarcinoma, in particular, and may also join EGFR mutational analysis as a marker for sensitivity to chemoradiation.
Fifty-one percent (41/81) of the BRCA-likeCGH tumors were ER-positive, making this the first study reporting on a potential marker for sensitivity to intensified DSB-inducing agents within the sporadic ER-positive breast cancer population.
Furthermore when discussing our findings that NQO1 is a marker for sensitivity of TNBC to 17-AAG we should have cited Papillon-Cavanagh et al. [ 2] as a previous paper where similar results were reported.
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The identification of predictive markers for sensitivity to PARP inhibition is a priority area for research.
These results suggest the possibility that p16 and cyclin E might serve as predictive markers for sensitivity to pladienolide B derivative.
Recent reports have shown that there are differences between gefitinib responders and non-responders in the frequency of activating mutations in the EGFR gene, which suggests that such mutations might be predictive markers for sensitivity to gefitinib [ 7, 8].
Recently, differences in the frequency of activating mutations in the EGFR gene between gefitinib responders and nonresponders were reported and these EGFR mutations seem to be predictive markers for sensitivity to gefitinib (Lynch et al, 2004; Paez et al, 2004).
Recent reports showing differences in the frequency of activating mutations in the EGFR gene between gefitinib responders and nonresponders suggest that these EGFR mutations are predictive markers for sensitivity to gefitinib (Lynch et al, 2004; Paez et al, 2004).
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