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Gene array technology has recently identified prostasin (a serine protease, previously identified in prostatic secretions), osteopontin (a secreted bone morphogen) and creatine kinase B (a marker for renal and lung cancers) to be elevated in serum from patients with ovarian cancer (Mok et al, 2001; Kim et al, 2002).
To date, however, the development of an early marker for renal dysfunction in the ICU remains elusive [17].
PTGDS is involved in the advancement of kidney diseases, and has been proposed in the past years as a potential diagnostic marker for renal injury [29].
Cystatin C is also known to be a better marker for renal injury than creatinine [15], [16].
In the kidney, cadherin-9 is a specific marker for renal fibroblasts, but it is not a general marker for fibroblasts in humans.
The classical type II cadherin-9, so far only described in the neural system, was identified as a reliable surface marker for renal fibroblasts.
Similar(13)
Objective: To investigate markers of tubular injury (glutathione-S-transferase [GST] isoforms) as early markers for renal damage in patients undergoing abdominal aortic aneurysm repair.
Creatinine clearance rate, sodium reabsorption, and renal oxygen handling efficiency were considered markers for renal function.
We assessed creatinine and cystatin C as markers for renal glomerular filtration rate and troponin I as marker for cardiac muscle tissue injury.
Consistent with these results was the expression of genes considered reliable markers for renal failure, such as Ngal, KIM1, and Ho1.
Moreover, new markers for renal stem/progenitor cells will be probably identified in the future and that the results obtained in this study will potentially need to be updated.
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