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Sluimer et al 21 identified that more generalised whole-brain atrophy may reflect rapid disease progression in comparison with more localised hippocampal atrophy in slow progressing AD; Karas et al 22 suggested the precuneus as a marker for progression of early-onset AD.
Aberrant upregulation of COX-2 enzyme resulting in accumulation of PGE2 in a cancer cell environment is a marker for progression of many cancers, including breast cancer.
Although CYFRA is a sensitive marker for non-small-cell lung cancer [16], it was a very sensitive marker for progression and metastases in the present case (Fig. 7).
The aim of this study was (1) to determine the longitudinal progression of FVCpp in patients with MDC1A, analyzing both ambulatory and non-ambulatory cohorts as well as those on or not on ventilation support (VS) and (2) to determine if FCVpp is a viable outcome marker for progression of disease.
Further, the role of BME as a marker for progression of OA is open to discussion.
Our primary endpoint, albuminuria, is a surrogate marker for progression of loss of kidney function.
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In particular, miR-200b was found to be a promising prognostic marker for progression-free and overall survival [ 94].
Multiple studies in breast cancer have shown that pathological complete response (pCR) serves as a reliable surrogate marker for progression-free survival, as well as overall survival [ 1– 6].
These circulating tumor cells (CTCs) have left the primary tumor and studies have confirmed that the CTC count per unit of blood is an independent prognostic marker for progression-free survival and overall survival in several types of cancer [ 13– 15].
DNA methylation markers could serve as useful biomarkers, both as markers for progression and for urine-based diagnostic assays.
Higher levels of IL-6 and IL-8 early in course of infection may be prognostic markers for progression to DHF and seem to play a role in the disease pathogenesis.
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