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An increase in oxidative stress proteins is an indirect marker for production of reactive oxygen species (ROS) [ 54].
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Assuming that the ratio of Aβ42 to total Aβ production in the brain increases in AD, we reasoned that a surrogate marker for Aβ42 production would be a potential biomarker for progression of AD pathology.
Two constructs for transposition-based insertion of the enhanced green fluorescent protein (eGFP), as well as for in vivo excision of the selection marker for the production of full-length proteins were engineered.
A strong immunostaining for nitrotyrosine (a marker for the production of peroxynitrite) was noted in the renal tubules at the end of both rounds of therapy suggestive of a causal association of this toxic NO-metabolite with capillary leakage in the kidneys.
The different metabolic trajectories of subjects in the trial's control group and its active arm were evident at three months — the earliest point at which a surrogate marker for insulin production was measured.
Phosphorylated tyrosine hydroxylase (a marker for dopamine production) was significantly elevated in ZI and higher in VTA (although not significantly) in neglectful mice.
It must be noted, however, that there exists heterogeneity of gene expression in myofibroblastic cells during fibrogenesis which reduces the usefulness of α-SMA as a marker for collagen production [36].
We propose using the levels of APL1β28 as a surrogate marker for Aβ42 production in the central nervous system.
However, the infrequency of the mev pathway in ABBA PTase-containing genomes indicates that it is not a reliable marker for HI production.
These include the ESM1 gene, a marker for isothiocyanate production (AT3G14210, [ 25, 26]) which was inferred to be up-regulated in P. fastigiatum in all ten datasets.
»…APLP1β28 levels in CSF as a surrogate marker for Aβ42 production in the brain.« The findings discussed above suggest that one can assess γ-secretase cleavages relevant to AD pathogenesis in a novel, straightforward fashion using APLP1β28 levels in CSF as a surrogate marker for Aβ42 production in the brain.
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