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Bonelli, M. et al. CD4+CD25−Foxp3+ T cells: a marker for lupus nephritis?
The lab tests say you have one marker for lupus, and another test says Sjogren's syndrome".
Anti-nuclear antibodies (ANAs) are highly prevalent and a major diagnostic marker for lupus.
CD4+CD25-Foxp3+ T cells resemble a marker for lupus nephritis.
From previous study reports, increased erythrocyte-bound C4d (E-C4d) was also a useful marker for lupus disease activity except in condition with haemolytic anemia (HA) and chronic renal failure (CRF) [ 6, 16].
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We also assessed the suitability of conventional MRI as a surrogate marker for CNS lupus.
While exploring the usefulness of conventional MRI, we found that a large MRI signal is useful as a diagnostic and surrogate marker for CNS lupus.
In addition, baseline mean urinary MCP-1 levels were significantly correlated with both LN class and severity of LN flare, hence, the high specificity makes urinary MCP-1 become a non-invasive marker for determining lupus flare and LN class [78].
Anti-Sm antibodies, identified in 1966 by Tan and Kunkel, are highly specific serological markers for systemic lupus erythrematosus (SLE).
Our data nevertheless supported that TNFSF4 may act as marker of lupus nephritis.
Theoretically we can combine those two markers as indicator for lupus activity determination.
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