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The slowing of EEG oscillations has been used as a marker for intervention effects in clinical trials, but the results have varied.
Also, the number of scheduled visits is not a direct marker for intervention intensity because a subject may have had a second visit scheduled because she missed the previous appointment.
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What is particularly important, the circadian components here mapped could serve as a marker for interventions, therapeutic or other.
Clinically, the total APA is often used as a marker for nutritional intervention.
In such cases, urinary phosphorus excretion per creatinine clearance could be a useful marker for early intervention for phosphate restriction because of its inexpensive and minimally invasive features.
These types of analyses will not only facilitate development of unbiased hypotheses at the molecular level, but will also assist us in following the scent to the identification and characterization of novel targets and disease markers for pharmacological intervention, gene therapy and diagnosis.
What I'm hearing you say is that you need to specify a marker for the specific intervention that you're trying to study – that there needs to be some surrogate in there somewhere.
Low CD1c + mDC counts were correlated with a high risk of rapid disease progression during EHI, suggesting a potentially important prognostic marker and a promising target for intervention.
However, it is unclear whether the effects of social adversity on immune-related biomarkers are evident in early life, and if these biomarkers may provide an early risk marker for targeting prevention and intervention.
In patients with elevated N-terminal pro-brain natriuretic peptide (NT-proBNP), as a marker for volume expansion, sodium intervention by diet, diuretic, or both, reduces blood pressure and proteinuria, whereas a normal NT-proBNP predicts a minor or nonsignificant effect (Fig. 4) [ 30].
If validated, this could be a useful marker for targeting smoking cessation interventions.
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CEO of Professional Science Editing for Scientists @ prosciediting.com