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Methods: Colonic specimens obtained from patients with slow-transit constipation (n = 11), patients with megacolon (n = 6), and a control group (n = 13, nonobstructing neoplasia) were stained with antibodies against c-kit (marker for interstitial cells of Cajal) and protein gene product 9.5 (neuronal marker).
We investigated whether N-cadherin could play a role as a discriminatory marker for interstitial cells in the human bladder.
As subpopulations of bladder ICs exist, another subclass of cadherins might account for a specific discriminatory marker for interstitial cells in the interfascicular planes of the detrusor layer.
CD90 might therefore be a good marker for interstitial tissue fibroblasts, but not for the FLSs forming the epithelium-like lining of the synovium.
This study was performed in search of a specific marker for interstitial cells in the human bladder and electron microscopic investigations of the same biopsies had to confirm the immunohistochemical findings.
N-cadherin can play a role as a discriminatory marker for interstitial cells in the human bladder, as the interstitial compartment of the human bladder houses a population of cells from mesenchymal origin, immunopositive for N-cadherin, vimentin, and C-kit.
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They describe discriminatory markers for interstitial cells and their role in detrusor overactivity.
Previous reports have suggested that KL-6, SP-A, and SP-D might be useful markers for interstitial pneumonias [ 4- 13, 29].
A small number of cells positive for FSP-1, a marker for renal interstitial fibroblasts [ 18, 19], arise via local EMT, express collagen type I, and expand by cell division during tissue fibrosis [ 12, 20].
To present a novel marker-flange, addressing source-reconstruction uncertainties due to the artifacts of a titanium intracavitary applicator used for magnetic resonance imaging (MRI -guided high-dose-rate (HDR) brachytherapy (BT); and to evaluate 7 different MRI -guidedagents used for interstitial prostate BT and intracavitary gynecologic HDR BT when treatment plans are guided by MRI.
Serum KL-6, a sialylated sugar chain on human MUC1, is used as a marker of interstitial lung diseases.
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