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While HBeAg is an important marker for infectivity, ideally, for every HBsAg-positive mother a viral load determination should be made, since it is possible to have a high viral load without being HBeAg positive [ 16].
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HBsAg is determined for HBV followed by a confirmatory HBsAg test and tests for HBeAg (marker for high infectivity), anti-HBc and anti-Hbe (marker for low infectivity).
In three of these the mothers were HBeAg positive (a marker for high infectivity).
In 3 of these, the mothers were HBeAg positive (a marker for high infectivity).
In the late 1970s in Japan, use of anti-HBe as a marker for low infectivity had been based on the observation (17 ) that anti-HBe seropositive canti-HBe seropositive to transmit hepatitis B sexually or to their infants.
It may also be because the HBsAg marker used to screen for HBV infection is a marker of infectivity and the anti-HCV marker used to screen for HCV infection is a marker of exposure.
Although protease-resistant PrP is often used as a definitive biological marker for TSE infection, the titer of infectivity measured by inoculation in experimental animals does not always fully correlate with the amount of PrP detected by immunoblot.
HBeAg is one of the serum marker for HBV infection and correlates with high infectivity.
We used standard IHC detection of PrPSc in tissues as a surrogate marker for transmission of infectivity to preclinical recipient sheep.
In the United Kingdom, the National Screening Programme for identification of hepatitits B virus (HBV) infection in pregnant women uses HBV e antigen (HBeAg) and antibody to HBeAg (anti-HBe) as markers of infectivity to determine use of immunoglobulin for hepatitis B. Serum samples from 114 HBV-infected women were analyzed.
Genetic markers of infectivity or likelihood of being a super-spreader could be used to justify quarantine and isolation policies, with the concomitant implications for individual liberty.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com