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Prostate specific antigen (PSA) protein in tumour cytosols was found to be an independent marker for favourable prognosis in breast cancer (Yu et al, 1995).
Gruvberger-Saal et al [ 38] reported that the expression of ERβ is an independent marker for favourable prognosis after adjuvant tamoxifen treatment in ERα negative breast cancer patients.
Here, we demonstrate that loss of PTEN expression in immunohistochemistry is an independent prognostic marker for favourable survival in endometrial carcinomas.
On the other hand, intentional weight loss during cardiac rehabilitation in patients with CAD (not MI) was a marker for favourable long-term (6.4 years) outcomes, in both subgroups with initial BMI < 25 or ≥25 kg/m [ 53].
Quite surprisingly, stratified analyses of survival with respect to MSI status, differentiation, ploidi and tumour localisation disclosed that in MSS/MSI-L tumours, in tumours with aneuploid DNA pattern and in moderately differentiated tumours, strong HLA-DR expression turned out to be a marker for favourable prognosis.
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AIM2, RIG-I and NLRP3 inflammasomes in NPC tumour cells, as well as tumour-associated neutrophils were identified as new markers for favourable prognosis in NPC.
MSI is a well-established marker for a favourable prognosis [ 29].
The present data shows for the first time that MMP-2 negativity could serve as a marker for distinctly favourable prognosis in breast carcinoma patients.
It is interesting to note that, MMP-2 negativity in this patient group was a strong marker for a favourable prognosis.
In this analysis, we identified strong expression of ALDH1A1 as a significant prognostic marker for more favourable overall survival in the subgroup of patients having been treated with adjuvant chemotherapy.
Interestingly, p16 positivity within the oropharynx appears to be at least as good a marker of favourable outcome, independent of whether samples also stained for HPV (Reimers et al, 2007; Ang et al, 2010).
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