The LM map was constructed utilising DArTs, SSRs, intron polymorphism (IP), and candidate gene-based markers for fatty acid desaturase and FLC genes.
Because palmitate is a reasonable marker for systemic fatty acid kinetics (23), total plasma fatty acid Ra/Rd was calculated by dividing plasma palmitate Ra/Rd by the percent contribution of palmitate to the total plasma fatty acid pool.
Citrate synthase, a non-iron containing citrate cycle enzyme, and long chain acyl-CoA dehydrogenase (LCAD), used as a marker for the fatty acid oxidation pathway, were unaffected by the iron deficiency.
Not only were the levels of the ETC proteins cytochrome c and succinate ubiquinone oxidoreductase markedly reduced, but LCAD, which we used as a marker for the fatty acid β-oxidation pathway, was increased ∼2-fold in the high fat diet fed rats.
Interestingly, there is also evidence for both positive and negative relationships with mortality for alanine transaminase (ALT), even though higher, not low, ALT is also considered a marker for nonalcoholic fatty liver disease.
For example, a review of the National Health and Nutrition Examination Survey NHANESS) found that PCB, lead, and mercury exposures were associated with elevated blood levels of alanine aminotransferase (ALT), a marker for nonalcoholic fatty liver disease (Cave et al. 2010a).
The results of our study provided further evidences that FLI could be considered as an easy and useful marker for screening fatty liver subjects in both general and special population.
Molecular markers for the fatty acid elongase 1 (Fand) and self- in) compatibility geneself- inlso been developed in our lab [ 25].
Serum γ-glutamyltranspeptidase (GGT), a marker of fatty liver disease (FLD), predicts mortality in young adults.
