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The results of this study are not only essential for a theoretical understanding of this invalidating condition, but also for providing an objective biological marker for fatigue that could support the diagnosis and follow-up of treatment.
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So far, no genomic markers for fatigue have been identified in patients undergoing VEGF inhibitor treatment.
8 HRV measurements are also promising as risk markers for fatigue, 48 ageing 49 and stress-situations.
No biologic or neuro-imaging markers for fatigue are currently known, and its pathophysiology and etiology are poorly understood.
Players from two junior teams (one high- and one low-standard) were tracked for markers of fatigue (neuromuscular and perceptual wellbeing) and muscle damage (blood creatine kinase [CK]) during an intensified rugby league competition.
At present, there are no clinically reliable disease markers for chronic fatigue syndrome.
A number of mitochondrial parameters were investigated as potential markers for the fatigue conditions.
The assessment of chronic fatigue syndrome was based on chronic water-immersion stress test for 10 min daily for 19 days and the immobility time was taken as the marker of fatigue.
Recovery represents an important marker of fatigue severity and biomarker responsiveness.
Although altered functioning in the hypothalamic-pituitary-adrenal axis, the serotonergic system, and associations with infectious agents have been identified, the search for genetic or epigenetic markers of fatigue, either in the context of CF or chronic fatigue syndrome (CFS) has been relatively unproductive or, in the case of epigenetics, nonexistent.
If the alternative pattern of autonomic functions is similar between CFS patients and fatigued healthy volunteers, the measurement of autonomic functions is useful as a common objective physiological marker for chronic and acute fatigue, as well as for evaluation of the effects of intervention against acute fatigue in order to prevent chronic fatigue.
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