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Shmelkov et al recently reported that CD133 may not be a reliable marker for colon CSCs.
These data are consistent with our in vitro observation that CtBP1 drives Wnt signaling and identifies CtBP1 as a potential marker for colon cancer progression.
These candidate miRNAs were selected because 1) miR-21 has been found to be upregulated in CRC tumor tissues [9], [10], [14]; 2) miR-92 has recently been reported to be a plasma marker for colon cancer [11]; and 3) miR-141 has been shown to be a potential plasma marker for metastatic prostate cancer [12].
SIRT3 may be considered as a marker for colon cancer.
It is also a negative marker for colon cancer discrimination [ 32].
ALDH1, largely reported as breast CSC marker [ 42, 43], is also a potential stem cell marker for colon cancer [ 44, 45].
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Dr. Ahlquist, who is a scientific adviser to the company, identified some of the highly methylated genes the company is testing as markers for colon cancer.
When all "inclusion" boxes are selected (Table S3B), the common tumor markers for colon, ovary, pancreas, and breast cancers are shown in Figure 3.
We believe that the identification of miR-141 may represent a key advancement in the search for valuable plasma markers for colon cancer that have the potential to be translated into clinical applications including prognosis, monitoring response to therapy, and detecting disease recurrence.
On the other hand, several miRNAs have recently been found as prognostic markers for colon cancer.
HNP 1-3 may serve as blood markers for colon cancer in combination with other diagnostic tools.
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