Sentence examples for marker for benefit from inspiring English sources
It also identified the first predictive marker for benefit from alkylating agent chemotherapy in glioblastoma, the methylation of the O6-methyl-guanyl-methly-transferase (MGMT) gene promoter.
MGMT promoter methylation status might be a useful predictive marker for benefit from temozolomide.
This result also suggests the definition of SMAD4 as a predictive marker for benefit of 5FU-based chemotherapy in patients with colorectal cancer.
Alternatively, methylation of the O-methylguanine DNA methyltransferase (MGMT) is the first predictive marker for benefit from alklyating agent therapy in the treatment of glioblastoma [ 60, 61].
Cyclin D1a was identified to be a predictive marker for benefit from adjuvant treatment with 5-FU/LEV in colon cancer both when we analysed stages II and III together and stage III alone.
For example, DNA methylation of MGMT is considered as both a prognostic marker for patients with glioblastomas as well as a predictive marker for benefit of the use of the DNA alkylating agent, temozolomide, in the management of this disease [ 2].
However, with the described methodology, predictive markers for benefit on cediranib treatment were not identified with consistent data between PFS and OS.
For other malignancies such as glioblastomas and colorectal cancer, the predictive significance of molecular markers for benefit from anti-EGFR treatment with small molecule tyrosine kinase inhibitors or monoclonal antibodies is proposed but remains to be further defined [ 18- 20].
Tissue inhibitor of metalloproteinase 1 (TIMP-1) protein as determined by immunhistochemistry is another potential molecular marker for anthracycline benefit [ 10].
In general, the value of progression-free survival, as a surrogate marker for patient benefit, has recently been subjected to critical reappraisal.
In particular, changes in SUV parameters over the course of treatment can serve as an early surrogate marker for clinical benefit (Kelloff et al, 2005).
