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Liver kidney microsomal antibody type 1 (LKM-1) is a diagnostic marker for autoimmune hepatitis type 2 (AIH-2).
For example, in the presence of an unexpected marker for autoimmune hepatitis, it should be indicated that the finding of such autoantibodies "could be associated with autoimmune hepatitis".
The ANA lab test is a marker for autoimmune disease and the C-reactive protein as well as ESR are markers for level of inflammation.
APA seroactivity is also not a general marker for autoimmune disease processes.
Glutamic acid decarboxylase GAD65 autoantibodies (GADA) are an established marker for autoimmune diabetes.
This result is in accordance with a precedent work [ 8], re-emphasizing the thesis that APA is not a general marker for autoimmune disease process.
Similar(51)
Widespread use of the ANA-reflex test for diagnosing such pathologies, however, is not advisable considering that only some of the markers for autoimmune hepatitis can be identified by ANA-IIF on HEp-2 cells.
She lights into the article itself, which described the use of markers for autoimmune disease to monitor women who have had breast implants, claiming it suffered numerous technical flaws.
Anti-LKM1 has been considered as one of the markers for autoimmune hepatitis type II characterised by fulminant onset and high inflammatory activity according to Imtec data.
However, these antibodies were not restricted to PBC but also found in patients with autoimmune (but not viral) hepatitis and primary sclerosing cholangitis implying that they may be a marker for an autoimmune liver process in general.
From a more pathophysiological point of view, Jarius et al. questioned in 2009 if the MRZR is specific to MS at all or should rather be considered as a general marker for CNS autoimmune diseases [ 11].
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