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We hypothesized that one of the analyzed cytokines and chemokines, or a combination is suited as a serological marker for asthma or certain phenotypes.
This knowledge would pave the way for a conclusive interpretation and validation of systemic immune mediators and the discovery of a serological marker for asthma or asthma phenotypes or severity respectively.
YKL-40 is also called chitinase-3-like-1 (CHI3L1) protein and may be a marker for asthma.
The use of FEV1/FEV6 will be also investigated during this trial as a marker for asthma control.
Several linkage regions in asthma families could be found in this extended sample, although again no linkage with P < 0.003 could be found with any marker for asthma.
The exhaled fraction of nitric oxide (FeNO) has been investigated as a marker for asthma control during pregnancy, but is expensive and not easily accessible [ 26].
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There are few agreed definitions of severe asthma so we used hospital admissions and treatment category (according to British Thoracic Society Asthma Guidelines) as surrogate markers for asthma severity [ 23].
We used the severity markers for asthma symptoms and eczema symptoms that were developed for earlier ISAAC publications [ 31, 32], and both of these include sleep disturbance.
Participating mothers are mailed a questionnaire eliciting details on eco-epidemiological exposures and infant health and developmental outcomes including chronic markers for asthma, cardiovascular disease, and diabetes.
This suggests that commonly used markers for asthma, including IL-13 and chitinase, do in fact only reflect central airway inflammation.
Patterns of medication usage have also been evaluated, and those used for major asthma attacks - such as nebulisers and oral steroids - appear to be valid markers for asthma severity [ 27].
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