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BARD1 VA>G07Met (1592 A>G) is an interesting marker for association studies on cancer risk.
However, a recent study demonstrated that the quantification of CPA may be used as a diagnostic marker for association of the agent in patients with diarrhea [ 8].
Using methylation status represented by M values (see the ' Methods' section), we tested each epigenetic marker for association with age in linear mixed models that included the random effect of kinship using SOLAR [ 52] (see the ' Methods' section).
But if a marker presents disequilibrium without a high missing rate then there is less evidence for genotyping error and it may be appropriate to keep the marker for association analysis.
As a suitable candidate gene, IL-6 might influence the development of chronic HBV infection; therefore, SNPs of IL-6 gene can be selected as useful marker for association study.
GWAS rely on the assumption that linkage disequilibrium (LD) enables one SNP to act as a surrogate marker for association to other sequence variants in the same region [ 131].
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In a second analysis, we tested each AFLP marker for associations between band frequency and altitude of the sampling site using a permutation scheme which accounted for the hierarchical structure in the data.
Additionally, initial results from genome‐wide association studies using 116,000 markers and the prospects of using 550,000 markers for association studies are presented.
The semi-perfect phylogeny trees are used as high-level markers for association study.
It appears that copy number variation of different gene variants might be considered as independent genetic markers for association analyses.
Testing DNA markers for association with complex traits at the genome-wide scale is now a reality.
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