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A sensitive and specific molecular imaging marker for angiogenesis, however, is still missing.
In view of this, BCAS3 could be a surrogate marker for angiogenesis in a reparative healing process or tumor progression to higher grade of malignancy, a common phenomenon in cell biology.
A marker for angiogenesis is endoglin (Dallas et al, 2008).
Thus, VEGF seems not to be an ideal surrogate marker for angiogenesis.
The plasma levels of VEGF are often used as surrogate marker for angiogenesis.
The microvessel density (MVD), a surrogate marker for angiogenesis, was quantified using Chalkley grid analysis.
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In addition, endometrial biopsy samples were used for immunodetection of markers for angiogenesis (Vascular Endothelial Growth Factor A, its receptor 2, as well as angiopoietin-2 and its receptor-tyrosine-kinase Tie2) during the estrous cycle (three mares, d 0, 5 and 10; one biopsy per mare).
Immunohistochemical markers for angiogenesis and lymphocytic infiltrate were semiquantitatively assessed in 25 breast tumors.
Surrogate markers for angiogenesis would be useful tools to study the effectiveness of antiangiogenesis drugs.
Immunohistochemistry of markers for angiogenesis (CD31) and cell proliferation (Ki67) and gene expression profiling of tumours were performed.
We examined the time-dependent regulation of typical gene markers for angiogenesis in tissue slice #1, containing articular cartilage and subchondral bone.
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