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The marker density required is determined by how quickly linkage disequilibrium (LD) decays in the population.
This study facilitates predicting the marker density required to effectively associate genotypes with traits in Chinese wheat genetic resources.
For many QTL studies, genetic resolution remains limited by the number of recombination events and/or the marker density required to fully delineate them.
The extent of LD defines the marker density required for genome-wide association mapping (GWAM).
The marker density required for conducting successful association mapping depends on the extent of linkage disequilibrium (LD) within a population.
It indicated the direct correlation of LD patterning with physical linkage of markers on chromosomes and marker density required in these genes.
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Understanding the patterns of LD across the genome will facilitate prediction of marker densities required for efficient association of genotypes with traits in Chinese wheat genetic resources at both the genome and chromosome levels.
Thus, quantifying the extent of LD is useful for knowing marker densities required to represent nonrecombining haplotype segments within discovery populations (Yan et al. 2009).
In the presence of high LD, lower marker density is required for a target region with greater potential for detecting markers strongly associated with the target gene polymorphism, even if distant physically.
In the context of animal and human GWP where the populations studied are generally composed of complicated pedigreed individuals, a greater marker density is required to capture the small LD caused by accumulated historical recombinations.
In all of these studies, the number of linkage groups fell short of the chromosome number, indicating that a higher marker density is required for complete coverage of the genetic map.
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