Sentence examples for marker coverage from inspiring English sources

Genome-wide marker coverage.

This collection of SNPs provided high-density marker coverage with the average density of 1 SNP per 2-kb.

CIM should ideally be performed after ensuring that marker coverage is sufficient to provide an unbiased estimation of background effects.

We investigated the validation performance on the basis of the discovery platform marker coverage, the predicted variant size and the allele frequency as evaluated in the discovery dataset.

We performed multipoint linkage analysis with dense marker coverage over all autosomes: nearly 4000 unlinked SNPs at an average distance of 1 cM.

The lack of associations in a large proportion of genes can also be attributed to inadequate marker coverage on the Affymetrix 500 k chip.

We evaluated the performance of IgC2N through a simulation study and assessed that it has at least 80% power to detect rare (1%) CNVs with sufficient marker coverage or sufficient variant size in datasets with larger sample size (N = 2000) while detecting common CNVs with similar size or marker coverage with datasets of smaller sample size (N = 200).

The marker densities and distances vary substantially between the different chromosomes, but given the uniform lengths of the pachytene bivalents, we interpret this as incomplete marker coverage rather than a difference in chromosome size.

In addition, the approach does not impose any restriction on the number of covering markers for calling a CNV, which allows for the detection of smaller CNVs with poor marker coverage.

The results showed that the best validation rate occurs for CNVs (variants of more than 1 kb in size), with no advantage for very large variants and that neither higher marker coverage nor higher MAF play a role (Figure 3A).

In conclusion, the lack of associations in BP candidate genes may be attributed to inadequate marker coverage on the genome-wide arrays, small phenotypic effects of the loci and/or complex interaction with life-style and metabolic parameters.