Over a wide range of simulation scenarios it was found to be more accurate than a two-marker composite likelihood method.
Correlations between peripheral T cell subsets and serum markers, composite measures of disease activity, and Health Assessment Questionnaire Disability Index score at baseline.
Correlations between peripheral B cell subsets, natural killer (NK) cells and monocyte subsets and serum markers, composite measures of disease activity, and Health Assessment Questionnaire Disability Index score at baseline.
Another way to reduce sample size requirements in rare disease studies is through selection of the outcome measure using a continuous outcome variable, a surrogate marker, a composite endpoint, or repeated measure outcome.
Individual baseline values and median levels of the six biomarkers are shown in Figure 2. The computed specificities, sensitivities, positive and negative predictive values, and AUCs of the single markers and the composite markers with regard to diagnosis of bacterial infection are shown in Table 3.
QTL analysis with simple sequence repeat (SSR) markers and composite interval mapping has identified three main-effect QTL assessed by spikelet fertility and growth during the reproductive stage, including qPSST-3, qPSST-7, and qPSST-9, respectively, on chromosomes 3, 7, and 9.
For these markers, a composite scale taking into account both number and intensity was used.
To investigate the diagnostic accuracy of the six single markers and the two composite markers in a relevant subgroup, an analysis of the 57 patients diagnosed as having COPD or asthma with acute exacerbation or pneumonia (excluding Mycobacterium tuberculosis infection) was performed.
Multiple linear regression analysis was carried out to assess the relationship between HVPG and a composite marker consisting of a collagen degradation marker, a collagen formation marker and a noncollagen degradation marker.
