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Thus, the diagnostic performance for marker combinations of CEA, IL-8 and CRP proved to be slightly better in the validation set.
The marker combinations of CEA + IL-8 and CEA + CRP each falsely determined seven of 52 healthy controls to be malignant.
Once target clusters are identified, dot plots of the clusters in distinct colors are evaluated on all pair-wise marker combinations of scatters and markers, and reviewed by an experienced flow cytometrist.
In the whole patient cohort, the marker combinations of high antigen levels of either uPA and/or uPAR, uPA and/or PAI-1 or uPAR and/or PAI-1 were found to be significantly associated with shorter DSS in univariate Cox's regression analyses (Additional file 1: Table S1).
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The most accurate estimation was achieved with the marker combination of n-alkanes and LCOH with a correction for FR.
As a result of transformation, this process is interrupted, as the vast majority of QNR/v-srcts cells express only the marker combination of progenitor cells.
Of the cells cultured for 10 days nearly 100% expressed the marker combination of erythroid progenitors, CD36, CD71 and glycophorin, and were devoid of the lymphocyte, monocyte or NK markers CD4, CD8, CD3, CD14, CD56.
The currently presented marker combination of serum CA125 and two cystic fluid mass-peaks (ROC AUC 0.94) was comparable to the above-mentioned algorithms [ 3, 4].
Three-marker combinations of EGF with MIP-1β, sCD40L, IL-1α or VEGF showed promising results with the top model comprising EGFNil, EGFAg-Nil and MIP-1βAg-Nil.
Multi-marker combinations of VEGF and EGFR were analysed and summarised in Table 3. Positive VEGF and negative EGFR expression were significantly associated with lack of complete pathologic response (P<0.001) compared with all other multi-marker combinations.
A second step of the test could be performed if positive IFN-γ/IP-10 results are obtained to measure three-marker combinations of EGF, sCD40L, MIP-1β, VEGF, IL-1α or TGF-α levels by ELISA or multiplex cytokine assays, to differentiate individuals with active TB from LTBI.
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