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Similarly, when the frequency of all possible two-, three-, and four-marker haplotypes was compared between diabetes cases and non-cases, significant differences were shown for all of the haplotypes in whites but for none of the marker combinations in African-Americans (Table S1).
Additionally, we performed multi-marker FBATs (35) incorporating all possible marker combinations in a specific CNVR.
Global p-values were obtained for single SNPs and for 2-, 3- and 4- marker combinations in a sliding window.
The top two marker combinations in SVM analysis were EGFNil/EGFAg-Nil/MIP-1βAg-Nil and EGFNil/EGFAg-Nil/IL-1αAg.
A comparison of 25 quadruplicate marker combinations in CPC and bone-marrow derived mesenchymal stromal cells showed a similar expression profile.
The optimal marker combinations in each of the cross-validation runs, receiver operating characteristic (ROC) curves with area under the curve (AUC) statistics, odds-ratios and relative risks were recorded.
Similar(50)
ROC AUC for the marker combination in the early stage EOC was 0.77, compared to 0.76 for CA125 alone.
Only two of these studies [ 45, 50] additionally provided data on multiple marker combination in bladder cancer patients whereas the other two studies [ 37, 39] reported the presence of each marker individually.
In each run, 93 and 46 samples were selected at random as the training and test sets, respectively, and the best marker combination in the logistic regression model was selected using a stepwise algorithm using Akaike's information criterion [ 37].
The lack of consensus on the optimal biochemical marker combination in RA is understandable given the varying outcomes from diverse studies in which their predictive value has been assessed.
When distinguishing benign and EOC ovarian cysts, the diagnostic ability of the marker combination in cyst fluid together with serum CA125 (ROC AUC 0.87) was almost the same as for CA125 alone (AUC 0.88).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com