It has been shown that reducing mutated prelamin A levels in progeria cells by splicing correction restores heterochromatin markers (Scaffidi and Misteli 2005).
Errors could be corrected by splicing together bits of different takes.
We're simply going to make the nerves indefinitely elastic by splicing radio links into them".
In these events, the splicing machinery can 'skip over' an exon by splicing it, thereby masking its contribution in the final RNA or protein product.
Segment six and seven encode two proteins which are generated by splicing.
Anthony explained that he had made his money in DC by splicing metro cards together.
In rat islets, acute stimulation by glucose modestly increased several ER stress markers including spliced Xbp1, ER chaperones, ATF3, CHOP and GADD34 [35].
While the lack of upregulation is puzzling, the fact that the other UPR markers, including spliced HAC1 are upregulated, strongly indicates that the UPR is activated.
We confirmed that these cells were under ER stress by measuring expression levels of typical ER stress markers, spliced XBP-1 and BiP.
Successful applications of inteins are often limited by splicing efficiency.
