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This molecule is often used as a 'mitochondrial marker' because it unambiguously traces its ancestry to α-proteobacteria and is localized not only in mitochondria but also in the hydrogenosome of Trichomonas and the mitosomes of Entamoeba and Giardia [11], [15], [54].
In 2013, I named Joan Beaumont's Broken Nation as a welcome – and early – precedent marker because it explored, with unflinching honesty, not only the horror of the first world war, but also its divisive, devastating social impact on Australia.
The bouncer was odd, to say the least - he scribbled across a tattoo on my wrist with permanent marker because it reminded him of an ex-boyfriend - but once inside we were more than happy we'd made the effort.
β-Lactoglobulin was selected as the protein marker because it is a major protein in milk and whey powder.
CREB is a broader marker because it can also be phosphorylated by changes in cAMP, which is regulated in part by G protein receptors.
Additionally, CLEC5A, a cell surface receptor, which is also involved in innate response, was included in the analysis as a reference marker because it has been proposed to be involved in the development of DHF [20].
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Indeed, we have previously shown that ET of ciliary muscle does not induce activation of inflammation markers because it does not imply perforation of the retina and the treatment area is anterior.
SNP (single nucleotide polymorphism) is more useful than other conventional markers, because it is the most abundant and stabile type of genetic variation in most genomes [ 13– 15].
This approach is favoured for dominant markers because it provides reasonable estimates of the null allele frequency at each locus (Bonin et al. 2007).
It would be of great importance to fully understand the biology of individual proteins used as markers, because it can provide a new point of view on the seemingly contradictory results from individual studies.
Therefore, FGF23 level can be one of the candidate new markers, because it reflects the progression of CKD-MBD, can be easily followed up longitudinally from the early stages of CKD, and can predict outcomes.
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