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We utilize a marker assignment consistency heuristic: a genetic marker can only serve as causal anchor for one trait.
Differences in marker density, and errors in marker assignment because of repetitiveness of sequences, may account for the greater error rates near centromeres and telomeres.
It is worth noting that since neither RH mapping nor BAC fingerprinting were able to accurately map the NOR region, more attention should be paid to marker assignment and sequencing in this "problematic" region.
A six dimensional pooling geometry represented the best compromise to achieve a high efficiency in unambiguous marker assignment to BAC clones, while reducing considerably the number of PCR assays.
Bin mapping these markers using a subset of 10 progeny confirmed the ability to place markers within 10 cM bins, enabling increased efficiency in marker assignment and targeted map refinement.
Again, to be precise, the marker assignment to each drug is represented by a barcode or Boolean vector Y j = y j 1,…, y jm ), where y jl =1 if marker l is used to inform the treatment with drug j and 0 otherwise.
Similar(52)
In addition, all 31 bovine (and ovine/caprine) syntenic groups have been definitively assigned to specific chromosomes on the basis of official marker assignments performed with both G/Q and R-banded chromosomes of cattle (Hayes et al. 2000), as well as in those of both sheep and goat chromosomes (Di Meo et al. 2003).
However, to reduce the computational complexity of the problem, we will impose the sample protocol g best, c, assign at most two markers to each drug and optimize over marker assignments to drugs and the drug-to-sample protocols.
Consequently, co-dominant marker assignments and two haplotypes per strain were used in the subsequent analyses.
The simulated-annealing algorithm can get trapped in drug marker assignments that are suboptimal.
In instances where multiple matches to several different linkage groups were detected, all with relatively low e-values, the marker assignments were ignored.
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