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Moreover, microbiological and inflammatory marker assessment of NLF can provide information about the prevalence and impact of compartmentalised airway infection in various respiratory diseases, for example ventilator-associated pneumonia and sepsis.
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Our aims were to establish the marker of greatest prognostic utility and to investigate whether a multi-marker assessment of proliferation offered additional prognostic value compared with a single marker.
Animal models are developed and deployed for a variety of purposes, including: identification of biological substrates and pathogenic mechanisms; elucidation and validation of therapeutic targets and diagnostic markers; assessment of risks associated with new interventions; and translation of preclinical insights into clinical practice.
The correlation was also modest between these markers' assessments of the reports suggesting that the two groups of markers were not using the same criteria to reach their decision, despite being provided with descriptors and a mark scheme.
The clinical validation of biomarkers remains challenging given the multitude of marker assessment methods and the possibility that one drug can affect several molecular pathways.
The former authors found an association between image response and tumor marker assessment at 4 weeks of therapy.
Results of immunohistochemical marker assessment are presented in Table 1.
Thus, FOXP3 demethylation may be used as a good quantitative and indirect qualitative marker and valid method in multicenter field studies, offering the possibility of an additional or potentially substitute marker for assessment of Tregs.
Furthermore, FLT has been suggested as surrogate marker for assessment of response to treatment, especially when targeted drugs are utilized.
This indicates that IGFBP-3 can also serve as potential biochemical indicator of adolescent growth spurt and can be speculated as a potential biochemical marker for assessment of skeletal maturity, in a way similar to IGF-1.
Glycated hemoglobin (HbA1c) is the standard biochemical marker in assessment of diabetes.
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