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As will be demonstrated, the level of evidence required to formally and fully validate a new imaging marker as an appropriate end-point for phase II trials is substantial.
Here, we report a thionine mediated para-sulfonatocalix[4]arene capped AuNPs (pSC4-AuNPs) multilayers signal amplify strategy, which integrates nanoassembly with hybrid macrocyclic supramolecules nanomaterials for the sensitive detection of acetylcholinesterase (AChE) activity, by taking the assay of a neurological diseases marker as an example.
Using the CD31 marker as an indicator of emigration of naïve cells from the thymus, we performed a longitudinal study on cryopreserved PBMC obtained from MACS participants before, and after, initiation of ART.
Consequently, there is a demand for a reliable predictive surrogate marker as an early indicator of treatment efficacy.
Multiple Cox-proportional hazards regression was carried out to identify the protein marker as an independent predictor of survival.
We continue to include this marker as an option when assessing clinical trial specimens in which Th2 is considered a desired response.
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Human parvovirus B19 (B19) polymerase chain reaction (PCR) is now a routine analysis and serves as a diagnostic marker as well as a complement or alternative to B19 serology.
Fill in these with a marker as well.
ROC curves plot the performance of a diagnostic marker as a binary classifier.
"The bottom line is no single marker, as a general rule, has had the sensitivity to be able to be used as a definitive marker," says David Sidransky, a cancer specialist at Johns Hopkins Medical Institutions.
We first utilized a peptide-binding protein database to identify GRP78, a specific cancer cell-surface marker, as a target protein for the lead, L-peptide.
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