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Even moderate fever soon after head trauma or cerebral ischemia may markedly worsen brain injury.
Interestingly, dx null mutant phenotypes, which resemble N loss of function, markedly worsen with increased temperature (Wilkin et al., 2008).
The activity profiles of British children markedly worsen over the transition to adolescence, with over 40 min of PA daily being replaced by SED time over the 4 years of measurement.
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C. Headache has developed or markedly worsened during medication overuse.
During the 6-month period of OC therapy, the attacks markedly worsened, presenting with an almost weekly frequency.
A transesophageal echocardiography demonstrated markedly worsened dilation of the right ventricle with a very small left ventricle indicative of severe right heart strain.
The neurologist could and did enquire into the ICHD-II criterion: Headache has developed or markedly worsened during medication overuse [11].
Also, for the diagnosis of MOH, ICHD-3 beta criteria removes the item "headache developed or markedly worsened during medication overuse" making the diagnosis of MOH more relaxed.
Simple analgesics or any combination of ergotamine, triptans, analgesic opioids on ≥15 days/month on a regular basis for >3 months without overuse of any single class alone C. Headache has developed or markedly worsened during medication overuse.
Simple analgesics or any combination of ergotamine, triptans or opioids for ≥15 days/month on a regular basis for >3 months without overuse of any single class alone C. Headache has developed or markedly worsened during medication overuse.
Medication-overuse headache (MOH) is a secondary cause of chronic daily headache, where headaches occur 15 or more days per month when the therapeutic agent is used excessively and on a regular basis for 3 or more months, and when headaches have developed or markedly worsened during the period of medication overuse [1].
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