In stark contrast, Vangl2 was diffusely distributed in the optic vesicle cells of embryos that had been exposed to a high glucose concentration, and its expression was markedly weaker in these embryos (compare panels E and I in Fig. 4).
In general, the transcriptional expression of NSB genes is markedly weaker than that of genes located in SBs; however, several NSB genes functioning as secretory hydrolases and transporters are highly induced in solid-state cultivation and reach absolute expression levels comparable with those of SB genes.
From 10 weeks onward in lpr mice, Stat1 activation in response to exogenous stimulation was greatly reduced compared to MRL mice, but IFNγ was still able to induce some expression of target genes GBP-1 and IRF-1, though induction was markedly weaker than when Stat1 signal transduction was strong (Fig. 3C).
In further support of the transient nature of PROS expression in GCs, we observed that PROS protein signal in the OPC is markedly weaker after the third to fourth layer of postmitotic neurons as seen in whole mounts (e.g. Fig. 1F) and histological sections (data not shown).
In the latter group, tissue expression of MMP-2 presented as IRS score was significantly higher, whereas both TIMPs scored markedly weaker than in the SVGD patients.
Even then, the past three recoveries have been markedly weaker than those that came before.
And in constituencies where Ukip got a high share of the vote, the Tory to Labour swing was markedly weaker.
In comparison, the economic significance of order flow imbalance is markedly weaker.
Investors, business owners and ordinary Argentines grew more nervous, with the peso already markedly weaker on the black market.
Brazil's outlook is also markedly weaker, due to a lack of confidence among businesses and consumers.
