Sentence examples for markedly upregulated compared from inspiring English sources
In contrast, endogenous levels of total VEGFR-2 in HUVECs decreased slightly at 24 h after treatment with VEGF121/rGel, whereas p-VEGFR-2 levels after 24 h were markedly upregulated compared with the levels of untreated cells.
After androgen withdrawal, expression levels of phosphorylated p44/42 mitogen-activated protein kinase (MAPK) and Akt in LNCaP/IL-6 were markedly upregulated compared with those in LNCaP/Co; however, additional treatment with specific inhibitor of the MAPK or Akt signalling pathway significantly inhibited the growth of LNCaP/IL-6 compared with that of LNCaP/Co.
The same pattern was observed for the two GH7s: Expression of the gene containing a CBM1 (id 10483) was more than 30 times higher in the bottom section than in the top of the garden, while the gene with no CBM1 (id 24891) was only moderately upregulated in the bottom section compared to a high level in the top, but markedly upregulated compared to expression in the middle section (Table 1).
In patients with breast cancer, the miR-9 levels in primary tumors from patients with diagnosed metastases are markedly upregulated compared with those from metastasis-free patients.
In PVL mice, gastric mucosal epithelial apoptosis was significantly increased, and PUMA expression was also markedly upregulated compared with SO mice.
Real-time RT-PCR demonstrated that Slug overexpression markedly downregulated the mRNA levels of E-cadherin, whereas the mesenchymal markers fibronectin 1 and vimentin were upregulated, compared with A549/EGFP (Fig. 1B).
Proliferation rate of fibroblasts, keratinocytes, myoblasts and hepatocytes were significantly upregulated compared to the control.
Nevertheless, irrespective of whether myeloma cells themselves are capable of driving osteoclastogenesis in myeloma directly, it is incontrovertible that RANKL is over-expressed in the marrow micro-environment in myeloma patients, with the ratio of RANKL to OPG markedly upregulated as compared with that in normal control individuals [ 14].
THBS-1, a protein that inhibits angiogenesis by inducing apoptosis via activation of CD36 in microvascular endothelial cells, may be relevant to these mechanisms as well, as we found this pathway to be markedly upregulated in GBMs compared to lower grade gliomas.
Importantly, several genes responsible for EMT, stemness, tumorigenesis, and metastasis were markedly upregulated in MCF7-CT45A1 as compared with the control MCF7-V cells.
We confirmed that the overexpression of AQP3 mainly occurred in the cytoplasm and cell membrane in HCC tissues relative to adjacent nonneoplastic tissues and that AQP5 expression was markedly upregulated in HCC tissues compared with paired adjacent nonneoplastic tissues.
