Mice deficient in LDL receptor and apolipoprotein A-I, in which plasma cholesterol levels were markedly altered, suffered from increasingly severe ulcerated cutaneous inflammation, and, in these mice, cholesterol accumulation in the skin was associated with macrophage infiltration and was accompanied by increases in TNFα and COX-2 [ 29, 30].
Although the resort thrived during the Depression, it suffered markedly in the 1970s, when it was deserted by travelers for the lure of Europe and the Caribbean.
He suffered markedly from Parkinson's disease, and quite visibly struggled to carry out the tasks of his office, often fighting to hold up his head during public ceremonies.
In the late 1980s Egypt's economy suffered markedly from falling oil prices and was further weakened by a drop in the number of remittances from its three million workers abroad.
Not surprisingly, workers paid in cash (Congressman Grimm's alleged specialty) suffered markedly higher wage theft rates as those paid by check, including double the rate of minimum wage violations.
Your partner has been involved in long-term alcohol or drug abuse/addiction that they can't break free from and your life, or your childrens' lives, have suffered markedly because of it.
Its economy, however, suffers markedly from the small scale of much of its resource base, from restricted local markets, and from problems of transport to external markets.
Still, many state officials worry that New Jersey, with its heavy dependence on federal transportation dollars and its scores of Superfund sites, could suffer markedly in the years to come.
In his most recent letter Dr Khan wrote: "Being kept in appalling and inhuman conditions has seen my mental health markedly deteriorate, I suffer from almost constant depression and suicidal ideation".
But even if Page manages to get a good price, after some likely wrangles with shareholders, it is strange to see Adecco plumping for a company with significant exposure to Great Britain and the financial recruitment market two areas that could suffer markedly from the credit crunch and the wider economic slump.
