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We demonstrate that our approach could identify upstream biomarkers for a given set of signature genes with markedly smaller size and comparable performances.
Interestingly, in western blot experiments, the Δ(1 116 -TMEM16A protein showed a markedly smaller size compared to M1X-TMEM16A (80 vs. 100 kDa in deglycosylated samples) as evident from the faster electrophoretic mobility (Fig. 2B).
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The second is that these regulators may serve as better biomarkers by themselves than the original signature with markedly smaller sizes and better performance.
In addition, the size of the newly formed spheres was markedly smaller (sphere size is smaller than 50 µm) in the group treated with PDT (1.3 J/cm) in combination with autophagy inhibitors than in the control group or the group treated with PDT alone (Fig. 3C).
Micelles are markedly smaller in size as compared to typical diffusion film thickness.
Since the KO mice were markedly smaller in size compared to litter mates and it was previously reported that Wwox KO mice had defects in bone formation [16] we decided to perform bone analyses of our Wwox KO mouse.
All hMSC treated animals show a markedly smaller infarct size, while the application of human BM- and CD105-purified CB-hMSC could significantly reduce (p<0.05) the myocardial damage compared to MI-C (Figure 3B).
Several lines of evidence support that USP8 mutation contributes to ACTH hyperproduction: (1) USP8-mutated PAs expressed higher level of POMC mRNA, (2) patients with USP8-mutated PAs had similar levels of plasma ACTH, although PAs were markedly smaller in size, and (3) USP8 knockdown attenuated ACTH secretion in primary USP8-mutated tumor cells.
The crwn2 crwn4 and crwn1 crwn4 double mutants exhibited slightly smaller rosettes, while the remaining double mutants, crwn1 crwn2 and crwn1 crwn3, displayed markedly smaller rosette sizes.
However, clinical data are limited by markedly small sample sizes in some stage.
Additionally, previous studies examining CDT scores and driving behaviors have employed markedly small sample sizes, warranting future research with greater numbers of participants.
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