Sentence examples for markedly sensitized from inspiring English sources

We found that shRNA down-regulation of Metnase levels markedly sensitized these breast cancer cells to adriamycin-induced apoptosis (Fig. 3C).

Indeed, SNS-032 markedly sensitized HeLa and A549 cells to TRAIL-induced cell death.

Bcl2l1 knockdown did not increase basal α cell apoptosis (Fig. 5D), but it markedly sensitized the cells to palmitate.

Blockade of caspase-8 with zVAD-fmk or IETD-fmk markedly sensitized microglia to TNF and TLR1/2, TLR3, TLR4, and TLR7/8 ligation.

In contrast, caspase blockade did not prevent LPS-induced TNF secretion in primary rat microglia, but rather markedly sensitized the cells to LPS challenge.

In two other estrogen-deprived breast cancer lines, LTED and E8CASS, basal Bcl-2 level was greatly elevated and knockdown of Bcl-2 expression with siRNA markedly sensitized these cells to the apoptotic action of E2 [ 32].

Here, we show that MK-8776 markedly sensitizes multiple cell lines to gemcitabine.

Moreover, silencing of RRM2 by siRNA could enhance the DNA damage and markedly sensitize HCT-116 cells to camptothecin, a topoisomerase I inhibitor [ 47].

For example, PANDA interacts with the transcription factor NF-YA to limit the expression of pro-apoptotic genes; PANDA depletion markedly sensitizes human fibroblasts to apoptosis by doxorubicin.

Oxidative stress markedly sensitizes mitochondria toward mitochondrial membrane permeabilization induction and can also cause damage to nucleic acids and proteins [ 14].

Although TNF-α is not currently an anticancer agent for treatment of human cancers (because of side effects such as normal cell toxicity), low doses of TNF-α can markedly sensitize cancer cells to chemotherapy-induced apoptosis [ 26, 27].