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Furthermore, quercetin markedly restored Cu/Zn-SOD, CAT and GPx activities in the kidney of lead-treated rat.
The renal functional parameters including creatinine clearance, urinary sodium excretion, urinary osmolality, and solute-free reabsorption were also markedly restored in ischemia-ARF rats by administration of YJT.
Moreover, quercetin markedly restored Cu/Zn-SOD, Mn-SOD, CAT and GPx activities and upregulated mRNA expression levels of these proteins in the liver of lead-treated rat.
Polyuria caused by down-regulation of renal AQP 2 in the ischemia/reperfusion-induced ARF rats was markedly restored by administration of YJT (100 or 200 mg/kg, p.o). with restoring expression of AQP 2 in the kidney.
For neurons exposed to testosterone prior to A β, the fluorescent intensity of HSP70 was markedly restored).
Colony forming capacity of MLL/ENL leukemia cells attenuated by shEZH2 was markedly restored by p16 knockdown (Fig. 3b).
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Treatment with autophagy inhibitors (3-MA and Baf A1) or PERK inhibitor (GSK2656157), or knockdown of beclin1 or perk can markedly restore HSPC proliferation and definitive hematopoietic cell differentiation.
Interestingly, in p130Cas silenced cells the expression of Cox-2 markedly decreased, and was restored by re-expressing p130Cas.
Bosentan restored the markedly reduced gut oxygen delivery induced by endotoxin, in parallel with marked improvement of intestinal mucosal acidosis.
Finally, acquisition of cocaine self-administration is markedly reduced by ovariectomy, and restored by E2 replacement [ 86].
More strikingly, cells lacking vinculin showed a markedly suppressed contractility that was restored by transfecting the vinculin tail domain but not the head domain.
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