Of 20 non-synonymous sequence variants identified only in low absorbers, 14 markedly reduced expression of recombinant NPC1L1 when expressed in CHO-K1 cells.
Crosses of line KS110 to the KNAT1 over-expressing lines resulted in plants with markedly reduced expression of GFP in the o.i.2.
Both of PERK's direct substrates, EIF2A and NRF2, showed markedly reduced expression in transplanted islets.
Immunofluorescence showed a markedly reduced expression of laminin 5 protein whilst expression of collagen VII appeared to be normal.
Knockdown of MS4a4B by selected MS4a4B-siRNAs markedly reduced expression of MS4a4B at both RNA transcription and protein levels (Fig. 2C, 2D and Supplementary Fig. S3C).
Leptin-deficient ob/ob mice show a markedly reduced expression of Pgc-1α in brown adipose tissue, which is reverted by leptin treatment [49].
No significant differences were noticed between islets from wild-type mice and from LXRα-/-mice, while absence of LXRβ was associated with a markedly reduced expression of SCD1 and 2, and of SREBP1c (Figure 5b), and higher expression of DGAT1, SOAT1, and ELOvl5 (Table S2).
The second ALG14 mutation, p. Pro65Leu, results in markedly reduced expression in HEK293 cells.
Further, the target genes of cattle-specific miRNAs show markedly reduced expression compared to their pig and human orthologues.
Markedly reduced expression was observed in gastric cancer cell lines compared with that of normal gastric mucosa.
